Pathogenic microbes are responsible for billions of dollars in economic losses worldwide each year. In order to discover new antimicrobial molecules with good antimicrobial activity against P. fumigatus, C. albicans, E. fecalis, P. aeurogenosa, S. aureus, E. coli, S. mutans, K. pneumonia, A. niger. We sought to combine the active substructure of aryl-pyrimidines and aromatic amine derivatives together to design and synthesize novel 2H-4-aryl-aminopyrimidines derivatives.A series of novel 2H-4-aryl-aminopyrimidines derivatives were synthesized. The preliminary biological assays revealed that most of the synthesized compounds exhibit favorable antimicrobial activities against P. fumigates, C. albicans, E. fecalis, P .aeurogenosa, S. aureus, E. coli, S. mutans, K. pneumonia, A. niger .The activity of compounds Ia-Ie, IIa-IIe, IIIa-IIIe, IVa-IVe, Va-Ve, VIa-VIe were characterized and the synthesized compounds showed certain antimicrobial activities against P. fumigatus, .albicans, E. fecalis, P. aeurogenosa, S. aureus, E. coli, S. mutans, K. pneumonia, A. niger.
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